Annual and transition report of foreign private issuers pursuant to Section 13 or 15(d)

Collaborative Arrangements (Details Textual)

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Collaborative Arrangements (Details Textual) (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Research and development, net $ 19,659 $ 14,360 $ 9,755
Collaborative Arrangement [Member]
     
Research and development, net $ 3,200 $ 700 $ 1,200